New paper in Nature 2012.


I recently finished a lovely collaboration with Greg Finnigan, Tom Stevens, and Joe Thornton.  Our work shows how a molecular machine — in this case, a proton pump — increased in structural complexity over evolutionary time.  On a personal note, our project demonstrates the type of interdisciplinary work that can emerge when computational skills are combined with “wet” bench work.

Also, W. Ford Doolittle wrote a companion essay about our paper.


“Evolution of increased complexity in a molecular machine” — Finnigan, Hanson-Smith, et al. Nature 2012.

“Evolutionary biology: a ratchet for protein complexity” — Doolittle. Nature 2012.

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